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Article

Binding of substrate at the effector site of pyrophosphatase increases the rate of its hydrolysis at the active site.

Biochemistry. Biokhimiia - 1 Jan 2007

Sitnik T S, Avaeva S M

Abstract excerpt

It is shown that in addition to the active site, each subunit of Escherichia coli inorganic pyrophosphatase (E-PPase) contains an extra binding site for the substrate magnesium pyrophosphate or its non-hydrolyzable analog magnesium methylenediphosphonate. The occupancy of the extra site stimulates the substrate conversion. Binding affinity of this site decreased or disappeared upon the conversion of E-PPase into...

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Identifiers

PMID: 17309439
DOI: 10.1134/s0006297907010087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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