Article
ATP as effector of inorganic pyrophosphatase of Escherichia coli. The role of residue Lys112 in binding effectors.
Biochemistry. Biokhimiia - 1 Jan 2007
Rodina E V, Vorobyeva N N, Kurilova S A, Sitnik T S, Nazarova T I
Abstract excerpt
It has been shown that PP(i), methylenediphosphonate, and ATP act as effectors of Escherichia coli inorganic pyrophosphatase (E-PPase), and that they compete for binding at the allosteric regulatory site. On the basis of chemical modification and computer modeling of a structure of the enzyme-ATP complex, a number of amino acid residues presumably involved in binding effectors has been revealed. Mutant variants...
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