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An adenovirus prime/plasmid boost strategy for induction of equipotent immune responses to two dengue virus serotypes

15 Feb 2007

Abstract excerpt

BACKGROUND: Dengue is a public health problem of global significance for which there is neither an effective antiviral therapy nor a preventive vaccine. It is a mosquito-borne viral disease, caused by dengue (DEN) viruses, which are members of the Flaviviridae family. There are four closely related serotypes, DEN-1, DEN-2, DEN-3 and DEN-4, each of which is capable of causing disease. As immunity to any one...

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PMID: 17302980
DOI: 10.1186/1472-6750-7-10

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