Article
Genetic risk profiles for cancer susceptibility and therapy response.
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer - 1 Jan 2007
Bartsch Helmut, Dally Heike, Popanda Odilia, Risch Angela, Schmezer Peter
Abstract excerpt
Cells in the body are permanently attacked by DNA-reactive species, both from intracellular and environmental sources. Inherited and acquired deficiencies in host defense mechanisms against DNA damage (metabolic and DNA repair enzymes) can modify cancer susceptibility as well as therapy response. Genetic profiles should help to identify high-risk individuals who subsequently can be enrolled in preventive measures...
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