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Article

Forced expression of hic-5, a senescence-related gene, potentiates a differentiation process of RCT-1 cells induced by retinoic acid.

The international journal of biochemistry & cell biology - 1 Jan 1998

Shibanuma M, Nose K

Abstract excerpt

The hic-5 gene encodes the novel LIM protein which has been implicated in cellular senescence and differentiation processes. Previous studies of rat calvarial cells stimulated to differentiate by addition of retinoic acid (R.A.) showed a four-fold increase in hic-5 expression which preceded an increase in the expression of the differentiation markers, alkaline phosphatase and alpha (I) pro-collagen mRNA. These...

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PMID: 9597752
DOI: 10.1016/s1357-2725(97)00155-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Forced expression of hic-5, a senescence-related gene, potentiates a differentiation process of RCT-1 cells induced by retinoic acid.PMID 9597752Read ↗

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