Article
The role of mitochondrial dysfunction in bipolar disorder.
Drug news & perspectives - 1 Dec 2006
Kato Tadafumi
Abstract excerpt
Altered energy metabolism and accumulated mitochondrial DNA (mtDNA) mutations in the brain, associated mtDNA polymorphisms/mutations or nuclear encoded mitochondrial genes, effects of mood stabilizers on mitochondria and comorbidity of mood disorders with mitochondrial disorders, together suggest the role of mitochondrial dysfunction in the pathophysiology of bipolar disorder. Mitochondrial dysfunction may be...
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