Basic data for bipolar disorders: genetics, neurobiology and pharmacology.

Abstract excerpt

Bipolar disorders are quite common (lifetime prevalence 1–2 %) and have a substantial genetic risk (total heritability about 80 %). However, the contribution of individual genes to the total genetic risk is very small. Accordingly, no specific genes are known which show a larger contribution. Nevertheless, many of the known genes involved encode for proteins important for neural plasticity, mitochondrial...

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