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Article

Beta-catenin overexpression in the mouse brain phenocopies lithium-sensitive behaviors.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2007

Gould Todd D, Einat Haim, O'Donnell Kelley C, Picchini Alyssa M, Schloesser Robert J, Manji Husseini K

Abstract excerpt

Lithium inhibits glycogen synthase kinase-3 (GSK-3) at therapeutic concentrations; however, it is unclear if this inhibition and its downstream effects on specific signaling pathways are relevant to the treatment of bipolar disorder and depression. One of the targets of GSK-3 is the transcription...

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PMID: 17299510
DOI: 10.1038/sj.npp.1301338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17299510-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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