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Article

Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin.

Blood - 1 Jun 2007

Gardenghi Sara, Marongiu Maria F, Ramos Pedro, Guy Ella, Breda Laura, Chadburn Amy, Liu YiFang, Amariglio Ninette, Rechavi Gideon, Rachmilewitz Eliezer A, Breuer William, Cabantchik Z Ioav, Wrighting Diedra M, Andrews Nancy C, de Sousa Maria, Giardina Patricia J, Grady Robert W, Rivella Stefano

Abstract excerpt

Progressive iron overload is the most salient and ultimately fatal complication of beta-thalassemia. However, little is known about the relationship among ineffective erythropoiesis (IE), the role of iron-regulatory genes, and tissue iron distribution in beta-thalassemia. We analyzed tissue iron...

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Source

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Identifiers

PMID: 17299088
DOI: 10.1182/blood-2006-09-048868
PMCID: PMC1885515

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17299088-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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