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Article

Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia.

Blood - 19 Jun 2014

Suragani Rajasekhar N V S, Cawley Sharon M, Li Robert, Wallner Samantha, Alexander Mark J, Mulivor Aaron W, Gardenghi Sara, Rivella Stefano, Grinberg Asya V, Pearsall R Scott, Kumar Ravindra

Abstract excerpt

In β-thalassemia, unequal production of α- and β-globin chains in erythroid precursors causes apoptosis and inhibition of late-stage erythroid differentiation, leading to anemia, ineffective erythropoiesis (IE), and dysregulated iron homeostasis. Here we used a murine model of β-thalassemia inter...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24795345
DOI: 10.1182/blood-2013-06-511238
PMCID: PMC4064330

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24795345-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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