Article
Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation.
Proceedings of the National Academy of Sciences of the United States of America - 20 Feb 2007
Nan Xinsheng, Hou Jianghui, Maclean Alan, Nasir Jamal, Lafuente Maria Jose, Shu Xinhua, Kriaucionis Skirmantas, Bird Adrian
Abstract excerpt
Mutations in the human methyl-CpG-binding protein gene MECP2 cause the neurological disorder Rett syndrome and some cases of X-linked mental retardation (XLMR). We report that MeCP2 interacts with ATRX, a SWI2/SNF2 DNA helicase/ATPase that is mutated in ATRX syndrome (alpha-thalassemia/mental retardation, X-linked). MeCP2 can recruit the helicase domain of ATRX to heterochromatic foci in living mouse cells in a...
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