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Article

Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations.

Biochemical and biophysical research communications - 30 Mar 2007

Yamakawa Hidekuni, Oyama Satoko, Mitsuhashi Hiroaki, Sasagawa Noboru, Uchino Shigeo, Kohsaka Shinichi, Ishiura Shoichi

Abstract excerpt

Recently, neuroligins (NLs)3 and 4X have received much attention as autism-related genes. Here, we identified syntrophin-gamma2 (SNTG2) as a de novo binding partner of NL3. SNTG2 also bound to NL4X and NL4Y. Interestingly, the binding was influenced by autism-related mutations, implying that the impaired interaction between NLs and SNTG2 contributes to the etiology of autism.

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Source

Identifiers

PMID: 17292328
DOI: 10.1016/j.bbrc.2007.01.127

Genes

SNTG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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