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Article

Expression of splice variants of 1alpha-hydroxylase in mcf-7 breast cancer cells.

The Journal of steroid biochemistry and molecular biology - 1 Mar 2007

Cordes T, Diesing D, Becker S, Fischer D, Diedrich K, Friedrich M

Abstract excerpt

1,25-Dihydroxyvitamin D(3) (calcitriol) is the most active natural metabolite of Vitamin D(3). It has strong antiproliferative and differentiating effects on various cell types including breast cancer cells. 25-Hydroxyvitamin D(3)-1alpha-hydroxylase (1alpha-hydroxylase, CYP27B1) is one of the key enzymes in the formation of calcitriol. It has been found in breast cancer cells suggesting an autocrine regulation of...

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PMID: 17287116
DOI: 10.1016/j.jsbmb.2006.12.034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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