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Article

Affinity maturation of immunoglobulin A anti-tissue transglutaminase autoantibodies during development of coeliac disease.

Clinical and experimental immunology - 1 May 2007

Westerlund A, Ankelo M, Simell S, Ilonen J, Knip M, Simell O, Hinkkanen A E

Abstract excerpt

Coeliac disease (CD) is an immune-mediated enteropathy triggered by ingestion of wheat gluten and related cereals in genetically predisposed individuals. Circulating immunoglobulin A (IgA) class autoantibodies against tissue transglutaminase (IgA-TGA) are highly specific and sensitive serological markers for CD, which is ultimately confirmed by duodenal biopsy. Although CD is considered a life-long disorder,...

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Identifiers

PMID: 17286799
DOI: 10.1111/j.1365-2249.2007.03336.x
PMCID: PMC1868886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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