Article
Natural history of antibodies to deamidated gliadin peptides and transglutaminase in early childhood celiac disease.
Journal of pediatric gastroenterology and nutrition - 1 Sept 2007
Liu Edwin, Li Marcella, Emery Lisa, Taki Iman, Barriga Kathy, Tiberti Claudio, Eisenbarth George S, Rewers Marian J, Hoffenberg Edward J
Abstract excerpt
INTRODUCTION: Gliadin proteins play a key role in the pathogenesis of celiac disease; however, as a screen for celiac disease, anti-gliadin antibody testing has been replaced by the more sensitive and specific serological assays for transglutaminase autoantibodies (TGAA). A new generation of anti-gliadin antibody assays has been developed to detect synthetic, deamidated homologous gliadin peptides (DGP) with high...
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