Article
Interleukin-6 expression and gene polymorphism are associated with severity of periodontal disease in a sample of Brazilian individuals.
Clinical and experimental immunology - 1 Apr 2007
Moreira P R, Lima P M A, Sathler K O B, Imanishi S A W, Costa J E, Gomes R S, Gollob K J, Dutra W O
Abstract excerpt
Interleukin (IL)-6 is an inflammatory mediator involved in bone resorption. G/C polymorphism at position -174 of the IL-6 gene has been reported to influence IL-6 expression, with the G allele associated with higher expression levels. The aims of this study were to investigate the expression of IL-6 as well as the incidence of IL-6 (-174) gene polymorphism and their correlation to the severity of periodontitis in...
Topics
- Adolescent
- Adult
- Aged
- Cross-Sectional Studies
- Female
- Flow Cytometry
- Genetic Predisposition to Disease
- Genotype
- Humans
- Interleukin-6
- Leukocytes, Mononuclear