Polymorphism at position -174 of IL-6 gene is associated with susceptibility to chronic periodontitis in a Caucasian Brazilian population.

doi:10.1034/j.1600-051x.2003.20016.x

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Article

Polymorphism at position -174 of IL-6 gene is associated with susceptibility to chronic periodontitis in a Caucasian Brazilian population.

Journal of clinical periodontology - 1 May 2003

Trevilatto P C, Scarel-Caminaga R M, de Brito R B, de Souza A P, Line S R P

Abstract excerpt

BACKGROUND: Interleukin-6 (IL-6) is a multifunctional cytokine that mediates inflammatory tissue destruction. A G to C substitution at position -174 in the promoter of IL-6 gene reduces in vitro transcription of IL-6. This polymorphism has been associated with inflammatory diseases like chronic arthritis. OBJECTIVE: The aim of this study was to investigate the association between the IL-6-174 polymorphism and...

Topics

Adult
Alleles
Base Sequence
Brazil
Chi-Square Distribution
Chronic Disease
Cytosine
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Guanine

Humans

Inflammation Mediators

Interleukin-6

Male

Periodontitis

Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 12716337
DOI: 10.1034/j.1600-051x.2003.20016.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12716337-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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