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Article

Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form.

Haematologica - 1 Apr 2015

Pagani Alessia, Vieillevoye Maud, Nai Antonella, Rausa Marco, Ladli Meriem, Lacombe Catherine, Mayeux Patrick, Verdier Frédérique, Camaschella Clara, Silvestri Laura

Abstract excerpt

Transferrin receptor-2 is a transmembrane protein whose expression is restricted to hepatocytes and erythroid cells. Transferrin receptor-2 has a regulatory function in iron homeostasis, since its inactivation causes systemic iron overload. Hepatic transferrin receptor-2 participates in iron sensing and is involved in hepcidin activation, although the mechanism remains unclear. Erythroid transferrin receptor-2...

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Identifiers

PMID: 25637053
DOI: 10.3324/haematol.2014.118521
PMCID: PMC4380718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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