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Effects of age and gender on micronucleus and chromosome nondisjunction frequencies in centenarians and younger subjects

6 Feb 2007

Abstract excerpt

Studies have shown a significant increase in chromosome aneuploidy with age. The aim of this study was to elucidate whether the age-related changes in the level of hypoploidy correlate with the occurrence of micronuclei (MN) and chromosome nondisjunction (ND) in men and women. We analyzed cytokinesis-blocked (binucleated) lymphocytes treated with cytochalasin B, from 127 donors varying in gender and age including...

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PMID: 17284771
DOI: 10.1093/mutage/gem002

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