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Article

Changes in DNA Methylation Patterns in Subjects Exposed to Low-Dose Benzene

1 Feb 2007

Abstract excerpt

Aberrant DNA methylation patterns, including global hypomethylation, gene-specific hypermethylation/hypomethylation, and loss of imprinting (LOI), are common in acute myelogenous leukemia (AML) and other cancer tissues. We investigated for the first time whether such epigenetic changes are induced in healthy subjects by low-level exposure to benzene, a widespread pollutant associated with AML risk. Blood DNA...

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PMID: 17283117
DOI: 10.1158/0008-5472.can-06-2995

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