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Key Genetic and Epigenetic Mechanisms in Chemical Carcinogenesis.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Nov 2015

Ravegnini Gloria, Sammarini Gulia, Hrelia Patrizia, Angelini Sabrina

Abstract excerpt

DNA sequence and genetic factors alone cannot fully explain the many processes implicated in diseases initiation and development. It is now well understood that additional factors are involved in a final resulting phenotype. Epigenetic modifications, heritable changes not affecting the DNA sequence, are a key phenomenon at the basis of normal growth and differentiation. However, these can be defective leading to...

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PMID: 26500287
DOI: 10.1093/toxsci/kfv165

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