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Article

Acute myeloid leukemia following exposure to benzene more closely resembles de novo than therapy related‐disease

10 Jul 2013

Abstract excerpt

Benzene (Bz) is widely regarded as a prototype environmental leukemogen and individuals chronically exposed are at risk for myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). It is widely assumed that initiation and pathogenesis of AML following Bz exposure (Bz-AML) is similar or identical to therapy-related AML (t-AML), in which clonal cytogenetic abnormalities, including aneuploidy, are initiating...

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PMID: 23840003
DOI: 10.1002/gcc.22084

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