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Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells

5 Feb 2013

Abstract excerpt

Recent studies suggest that 7-dehydrocholesterol (7-DHC)-derived oxysterols play important roles in the pathophysiology of Smith-Lemli-Opitz syndrome (SLOS), a metabolic disorder that is caused by defective 3β-hydroxysterol-Δ(7)-reductase (DHCR7). Although 14 oxysterols have been identified as the primary products of 7-DHC autoxidation in organic solution, the metabolic fate of these oxysterols in a biological...

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PMID: 23381570
DOI: 10.1194/jlr.m035733

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