Article
Protection against myocardial ischemia-reperfusion injury by the angiogenic Masterswitch protein PR 39 gene therapy: the roles of HIF1alpha stabilization and FGFR1 signaling.
Antioxidants & redox signaling - 1 Apr 2007
Muinck Ebo D De, Nagy Norbert, Tirziu Daniela, Murakami Masahiro, Gurusamy Narasimman, Goswami Shyamal K, Ghatpande Satish, Engelman Richard M, Simons Michael, Das Dipak K
Abstract excerpt
PR-39, a proline-arginine-rich angiogenic response peptide, has been implicated in myocardial ischemic reperfusion injury. The present study examined the cardioprotective abilities of PR39 gene therapy. Male C57Bl/J6 mice were randomized to intramyocardial injecton of 10(9) p.f.u. adenovirus encoding PR39 (PR39), FGFR1 dominant negative signaling construct (FGFR1-dn), empty vector (EV), or PR39 adenovirus plus 4...
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