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Article

Cardioprotective effects of miR-34a silencing in a rat model of doxorubicin toxicity.

Scientific reports - 23 Jul 2020

Piegari Elena, Cozzolino Anna, Ciuffreda Loreta Pia, Cappetta Donato, De Angelis Antonella, Urbanek Konrad, Rossi Francesco, Berrino Liberato

Abstract excerpt

Cardiotoxicity remains a serious problem in anthracycline-treated oncologic patients. Therapeutic modulation of microRNA expression is emerging as a cardioprotective approach in several cardiovascular pathologies. MiR-34a increased in animals and patients exposed to anthracyclines and is involved in cardiac repair. In our previous study, we demonstrated beneficial effects of miR-34a silencing in rat cardiac cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32704131
DOI: 10.1038/s41598-020-69038-3
PMCID: PMC7378226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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