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Article

A partially linear tree-based regression model for assessing complex joint gene-gene and gene-environment effects.

Genetic epidemiology - 1 Apr 2007

Chen Jinbo, Yu Kai, Hsing Ann, Therneau Terry M

Abstract excerpt

The success of genetic dissection of complex diseases may greatly benefit from judicious exploration of joint gene effects, which, in turn, critically depends on the power of statistical tools. Standard regression models are convenient for assessing main effects and low-order gene-gene interactions but not for exploring complex higher-order interactions. Tree-based methodology is an attractive alternative for...

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PMID: 17266115
DOI: 10.1002/gepi.20205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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