Article
Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein.
Diabetes - 1 Mar 1999
Arden S D, Zahn T, Steegers S, Webb S, Bergman B, O'Brien R M, Hutton J C
Abstract excerpt
A pancreatic islet-specific glucose-6-phosphatase-related protein (IGRP) was cloned using a subtractive cDNA expression cloning procedure from mouse insulinoma tissue. Two alternatively spliced variants that differed by the presence or absence of a 118-bp exon (exon IV) were detected in normal balb/c mice, diabetic ob/ob mice, and insulinoma tissue. The longer, 1901-bp full-length cDNA encoded a 355-amino acid...
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