Article
Experimental modulation of the differentiated phenotype of keratinocytes from epidermis and hair follicle outer root sheath and matrix cells.
Annals of the New York Academy of Sciences - 26 Dec 1991
Limat A, Breitkreutz D, Stark H J, Hunziker T, Thikoetter G, Noser F, Fusenig N E
Abstract excerpt
Follicles of human anagen hair were separated into morphologically distinct compartments (by sequential trypsinization and microdissection) for the biochemical and immunological analysis of keratins as differentiation markers to diagnose the type of epithelial differentiation. While outer root sheath contained throughout the "soft" (cyto)keratins K5, 6, 14, 16, and 17, and hair cortex contained exclusively a set...
Topics
- Cell Differentiation
- Cells, Cultured
- Cytoskeletal Proteins
- Electrophoresis, Polyacrylamide Gel
- Epidermal Cells
- Epidermis
- Filaggrin Proteins
- Hair
- Humans
- Keratinocytes