Article
Age at first birth and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.
Breast cancer research and treatment - 1 Oct 2007
Kotsopoulos Joanne, Lubinski Jan, Lynch Henry T, Klijn Jan, Ghadirian Parviz, Neuhausen Susan L, Kim-Sing Charmaine, Foulkes William D, Moller Pal, Isaacs Claudine, Domchek Susan, Randall Susan, Offit Kenneth, Tung Nadine, Ainsworth Peter, Gershoni-Baruch Ruth, Eisen Andrea, Daly Mary, Karlan Beth, Saal Howard M, Couch Fergus, Pasini Barbara, Wagner Teresa, Friedman Eitan, Rennert Gad, Eng Charis, Weitzel Jeffrey, Sun Ping, Narod Steven A, Garber J, Osborne M, Fishman D, McLennan J, McKinnon W, Merajver S, Olsson H, Provencher D, Pasche B, Evans G, Meschino W S, Lemire E, Chudley A, Rayson D, Bellati C
Abstract excerpt
An early age at first full-term birth is associated with a reduction in the subsequent development of breast cancer among women in the general population. A similar effect has not yet been reported among women who carry an inherited BRCA1 or BRCA2 mutation. We conducted a matched case-control study on 1816 pairs of women with a BRCA1 (n = 1405) or BRCA2 (n = 411) mutation in an attempt to elucidate the...
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