Article
Thyroglobulin gene mutations producing defective intracellular transport of thyroglobulin are associated with increased thyroidal type 2 iodothyronine deiodinase activity.
The Journal of clinical endocrinology and metabolism - 1 Apr 2007
Kanou Yasuhiko, Hishinuma Akira, Tsunekawa Katsuhiko, Seki Koji, Mizuno Yutaka, Fujisawa Haruki, Imai Tsuneo, Miura Yoshitaka, Nagasaka Tetsuro, Yamada Chizumi, Ieiri Tamio, Murakami Masami, Murata Yoshiharu
Abstract excerpt
CONTEXT: Most patients with defective synthesis and/or secretion of thyroglobulin (Tg) present relatively high serum free T3 (FT3) concentrations with disproportionately low free T4 (FT4) resulting in a high FT3/FT4 ratio. The mechanism of this change in FT3/FT4 ratio remains unknown. OBJECTIVE: We hypothesize that increased type 2 iodothyronine deiodinase (D2) activity in the thyroid gland may explain the higher...
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