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Somatic cell nuclear transfer in the sheep induces placental defects that likely precede fetal demise

1 Jan 2007

Abstract excerpt

The efficiency of cloning by somatic cell nuclear transfer (SCNT) is poor in livestock with approximately 5% of transferred cloned embryos developing to term. SCNT is associated with gross placental structural abnormalities. We aimed to identify defects in placental histology and gene expression in failing ovine cloned pregnancies to better understand why so many clones generated by SCNT die in utero. Placentomes...

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PMID: 17244750
DOI: 10.1530/rep.1.01203

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