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Low levels of exosomal-miRNAs in maternal blood are associated with early pregnancy loss in cloned cattle

24 Oct 2017

Abstract excerpt

Nuclear reprogramming mediated by somatic cell nuclear transfer (SCNT) has many applications in medicine. However, animal clones show increased rates of abortion and reduced neonatal viability. Herein, we used exosomal-miRNA profiles as a non-invasive biomarker to identify pathological pregnancies. MiRNAs play important roles in cellular proliferation and differentiation during early mammalian development. Thus,...

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PMID: 29085015
DOI: 10.1038/s41598-017-14616-1

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