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Somatic cell nuclear transfer is associated with altered expression of angiogenic factor systems in bovine placentomes at term

1 Jan 2010

Abstract excerpt

Low efficiency of somatic cell cloning by nuclear transfer has been associated with alterations of placental vascular architecture. Placental growth and function depend on the growth of blood vessels; VEGF-A and bFGF are the most important factors controlling neovascularization and vascular permeability in the placenta. We hypothesize that the VEGF-A and bFGF systems are disrupted in placentomes from cloned...

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PMID: 20198587
DOI: 10.4238/vol9-1gmr729

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