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Article

Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states.

Nature medicine - 1 Feb 2007

Cohn Ronald D, van Erp Christel, Habashi Jennifer P, Soleimani Arshia A, Klein Erin C, Lisi Matthew T, Gamradt Matthew, ap Rhys Colette M, Holm Tammy M, Loeys Bart L, Ramirez Francesco, Judge Daniel P, Ward Christopher W, Dietz Harry C

Abstract excerpt

Skeletal muscle has the ability to achieve rapid repair in response to injury or disease. Many individuals with Marfan syndrome (MFS), caused by a deficiency of extracellular fibrillin-1, exhibit myopathy and often are unable to increase muscle mass despite physical exercise. Evidence suggests that selected manifestations of MFS reflect excessive signaling by transforming growth factor (TGF)-beta (refs. 2,3)....

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Identifiers

PMID: 17237794
DOI: 10.1038/nm1536
PMCID: PMC3138130

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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