Article
Cerebral angiogenic factors, angiogenesis, and physiological response to chronic hypoxia differ among four commonly used mouse strains.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 May 2007
Ward Nicole L, Moore Elizabeth, Noon Kristen, Spassil Nicholas, Keenan Erica, Ivanco Tammy L, LaManna Joseph C
Abstract excerpt
Angiogenesis is a critical element for adaptation to low levels of oxygen and occurs following long-term exposure to mild hypoxia in rats. To test whether a similar response in mice occurs, CD1, 129/Sv, C57Bl/6, and Balb/c mice were exposed to 10% oxygen for up to 3 wk. All mice showed significant increases in the percentage of packed red blood cells, and CD1 and 129/Sv mice showed increased respiration frequency...
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