Article
2-methoxyestradiol inhibits the anaphase-promoting complex and protein translation in human breast cancer cells.
Cancer research - 15 Jan 2007
Bhati Rajendra, Gökmen-Polar Yesim, Sledge George W, Fan Cheng, Nakshatri Harikrishna, Ketelsen David, Borchers Christoph H, Dial Michael J, Patterson Cam, Klauber-DeMore Nancy
Abstract excerpt
2-methoxyestradiol (2ME2), an estradiol metabolite with antiproliferative and antiangiogenic activities, is in phase I/II clinical trials for breast cancer. 2ME2 inhibits microtubule polymerization and causes cells to arrest in G2-M. The purpose of this study was to further elucidate the molecular mechanism of 2ME2. MDA-MB-435 breast cancer cells were treated with 2ME2 (2 micromol/L) or vehicle alone. RNA was...
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