Reck Gene Expression in Hepatocellular Carcinoma: Correlation With Invasion–Related Clinicopathological Factors and Its Clinical Significance

Abstract excerpt

The RECK (reversion-inducing-cysteine-rich protein with Kazal motifs) gene was initially isolated as a transformation suppressor gene. It encodes a membrane-anchored glycoprotein with multiple serine protease inhibitor-like domains. The RECK gene is expressed widely in normal organs but is undetectable in many tumor-derived cell lines. When artificially expressed in such cell lines, RECK suppresses their invasive...

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