Article
Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma.
International journal of cancer - 15 Apr 2007
Song Xu-Hong, Liang Bin, Liu Ge-Fei, Li Rui, Xie Jian-Ping, Du Kun, Huang Dong-Yang
Abstract excerpt
NADP(H)-dependent retinol dehydrogenase/reductase (NRDR) plays an important role in maintaining the homeostasis of retinoid. Aberrations in retinoid metabolism are considered as early events in carcinogenesis. We identified a novel alternatively spliced variant, NRDRB1, in HeLa cell and human cervical squamous carcinoma tissues, which is characterized by a complete deletion of exon 3. The latter resulted in...
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