Article
Docosahexaenoic acid stabilizes soluble amyloid-beta protofibrils and sustains amyloid-beta-induced neurotoxicity in vitro.
The FEBS journal - 1 Feb 2007
Johansson Ann-Sofi, Garlind Anita, Berglind-Dehlin Fredrik, Karlsson Göran, Edwards Katarina, Gellerfors Pär, Ekholm-Pettersson Frida, Palmblad Jan, Lannfelt Lars
Abstract excerpt
Enrichment of diet and culture media with the polyunsaturated fatty acid docosahexaenoic acid has been found to reduce the amyloid burden in mice and lower amyloid-beta (Abeta) levels in both mice and cultured cells. However, the direct interaction of polyunsaturated fatty acids, such as docosahexaenoic acid, with Abeta, and their effect on Abeta aggregation has not been explored in detail. Therefore, we have...
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