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Identification and functional characterization of genetic variants of human organic cation transporters in a Korean population.

Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 2007

Kang Ho-Jin, Song Im-Sook, Shin Ho Jung, Kim Woo-Young, Lee Choong-Hee, Shim Joo-Cheol, Zhou Hong-Hao, Lee Sang Seop, Shin Jae-Gook

Abstract excerpt

Genetic variants of three human organic cation transporter genes (hOCTs) were extensively explored in a Korean population. The functional changes of hOCT2 variants were evaluated in vitro, and those genetic polymorphisms of hOCTs were compared among different ethnic populations. From direct DNA sequencing, 7 of 13 coding variants were nonsynonymous single-nucleotide polymorphisms (SNPs), including four variants...

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PMID: 17220237
DOI: 10.1124/dmd.106.013581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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