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Article

A function for keratins and a common thread among different types of epidermolysis bullosa simplex diseases.

The Journal of cell biology - 1 Dec 1991

Coulombe P A, Hutton M E, Vassar R, Fuchs E

Abstract excerpt

Previously we demonstrated that transgenic mice expressing a mutant keratin in the basal layer of their stratified squamous epithelia exhibited a phenotype bearing resemblance to a subclass (Dowling Meara) of a heterogeneous group of human skin disorders known as epidermolysis bullosa simplex (EBS) (Vassar, R., P. A. Coulombe, L. Degenstein, K. Albers, E. Fuchs. 1991. Cell. 64:365-380.). The extent to which...

Topics

Animals
Cloning, Molecular
Electrophoresis, Polyacrylamide Gel
Epidermolysis Bullosa Simplex
Keratins
Male
Mice
Mice, Transgenic
Microscopy, Immunoelectron
Mutation
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1721910
DOI: 10.1083/jcb.115.6.1661
PMCID: PMC2289221

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1721910-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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