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Article

Essential role of proline isomerization in stefin B tetramer formation.

Journal of molecular biology - 9 Mar 2007

Jenko Kokalj Sasa, Guncar Gregor, Stern Igor, Morgan Gareth, Rabzelj Sabina, Kenig Manca, Staniforth Rosemary A, Waltho Jonathan P, Zerovnik Eva, Turk Dusan

Abstract excerpt

Here we present the tetrameric structure of stefin B, which is the result of a process by which two domain-swapped dimers of stefin B are transformed into tetramers. The transformation involves a previously unidentified process of extensive intermolecular contacts, termed hand shaking, which occurs concurrently with trans to cis isomerization of proline 74. This proline residue is widely conserved throughout the...

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PMID: 17217964
DOI: 10.1016/j.jmb.2006.12.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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