Deletion of the carboxy terminal part of stefin B does not have a major effect for binding to papain.

Article

Deletion of the carboxy terminal part of stefin B does not have a major effect for binding to papain.

Biomedica biochimica acta - 1 Jan 1991

Jerala R, Kroon-Zitko L, Kopitar M, Popovic T, Turk V

Abstract excerpt

Determination of crystal structures of chicken cystatin and human stefin B complexed with papain revealed a novel model of protease inhibition and also structural differences between two cysteine proteinase inhibitor (CPI) families. According to the 3D alignment, stefins have an extension of 9 am...

Topics

Amino Acid Sequence
Animals
Base Sequence
Binding Sites
Chromosome Deletion
Cystatin B
Cystatins
DNA
Humans
In Vitro Techniques
Kinetics
Molecular Sequence Data
Mutation
Papain
Structure-Activity Relationship

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