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Article

Essential role of Pro 74 in stefin B amyloid-fibril formation: dual action of cyclophilin A on the process.

FEBS letters - 2 Apr 2009

Smajlović Aida, Berbić Selma, Schiene-Fischer Cordelia, Tusek-Znidaric Magda, Taler Ajda, Jenko-Kokalj Sasa, Turk Dusan, Zerovnik Eva

Abstract excerpt

We report that Pro74 in human stefin B is critical for fibril formation and that proline isomerization plays an important role. The stefin B P74S mutant did not fibrillate over the time of observation at 25 degrees C, and it exhibited a prolonged lag phase at 30 degrees C and 37 degrees C. The peptidyl prolyl cis/trans isomerase cyclophilin A, when added to the wild-type protein, exerted two effects: it prolonged...

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Identifiers

PMID: 19265692
DOI: 10.1016/j.febslet.2009.02.037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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