High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation.

Abstract excerpt

We show that human stefin B, a protease inhibitor from the family of cystatins, is a copper binding protein, unlike stefin A. We have used isothermal titration calorimetry to directly monitor the binding event at pH 7 and pH 5. At pH 7 stefin B shows a picomolar affinity for copper but at pH 5 the affinity is in the nanomolar range. There is no difference in the affinity of copper between the wildtype stefin B...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amyloid
• Share to Benzothiazoles