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Article

HIF and fumarate hydratase in renal cancer

9 Jan 2007

Abstract excerpt

Hereditary leiomyomatosis and renal cell cancer is a recently described hereditary cancer syndrome in which affected individuals are predisposed to the development of leiomyomas of the skin and uterus. In addition, this clinical entity also can result in the development of biologically aggressive kidney cancer. Affected individuals harbour a germline mutation of the fumarate hydratase (FH) gene, which encodes an...

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PMID: 17211469
DOI: 10.1038/sj.bjc.6603547

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