Article
Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene.
The Journal of biological chemistry - 14 Apr 2006
Iavarone Carlo, Acunzo Mario, Carlomagno Francesca, Catania Annunziata, Melillo Rosa M, Carlomagno Stella M, Santoro Massimo, Chiariello Mario
Abstract excerpt
Mitogen-activated protein (MAP) kinases have a central role in several biological functions, including cell adhesion and spreading, chemotaxis, cell cycle progression, differentiation, and apoptosis. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase whose activity is controlled by serum and the c-Src non-receptor tyrosine kinase. Here, we show that RET/PTC3, an activated form of the RET...
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