Article
Effect of the anti-tumor necrosis factor-alpha antibody infliximab on the ex vivo mucosal matrix metalloproteinase-proteolytic phenotype in inflammatory bowel disease.
Inflammatory bowel diseases - 1 Feb 2007
Meijer Martin J, Mieremet-Ooms Marij A C, van Duijn Wim, van der Zon Annie M, Hanemaaijer Roeland, Verheijen Jan H, van Hogezand Ruud A, Lamers Cornelis B H W, Verspaget Hein W
Abstract excerpt
BACKGROUND: Previous studies have shown an upregulation of matrix metalloproteinases (MMPs) in intestinal tissue of patients with inflammatory bowel disease (IBD) and significant clinical improvement after administration of the anti-TNF-a antibody infliximab. The aims of our study were to determine expression and secretion of MMP-1, -2, -3, -9, and their inhibitors TIMP-1, -2 by IBD versus control intestinal...
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