Article
[Development of a DNA chip screening mitochondrial DNA mutations in patients with diabetes mellitus].
Zhonghua yi xue za zhi - 31 Oct 2006
Liu Song-mei, Zhou Xin, Zheng Fang, Li Xia, Qin Han, Zhang Hong-mei, Li Dong
Abstract excerpt
OBJECTIVE: To establish a rapid and precise high-throughput mitochondrial (mt) DNA chip and to investigate the relationship between mtDNA tRNA Leu (UUR) and ND1 gene mutations and diabetes mellitus. METHODS: A wild-type and mutant probes of 28 loci in tRNA Leu (UUR) and ND1 gene were immobilized...
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