Article
HLA-B Bw4 alleles and HIV-1 transmission in heterosexual couples.
AIDS (London, England) - 11 Jan 2007
Welzel Tania M, Gao Xiaojiang, Pfeiffer Ruth M, Martin Maureen P, O'Brien Stephen J, Goedert James J, Carrington Mary, O'Brien Thomas R
Abstract excerpt
BACKGROUND: Genetic factors may play a role in the transmission of HIV-1. Because HLA-B alleles influence HIV-1 disease progression and viral levels, they might also influence HIV-1 transmission. OBJECTIVE: To investigate if the presence of HLA-B alleles with the Bw4 epitope in HIV-1-infected men decreased the risk of transmission to their female sex partners. METHODS: The study comprised 304 HIV-1-infected men...
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